JNJ 10191584 maleate
Cat. No. 2441
Alternative Name: VUF 6002
Chemical Name: 1-[(5-Chloro-1H-benzimidazol-2-yl)c
Biological ActivityHighly selective histamine H4 receptor silent antagonist; binds with high affinity to the human H4 receptor (Ki = 26 nM). > 540-fold selective over the H3 receptor (Ki = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Orally active in vivo.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Varga et al (2005) Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat. Eur.J.Pharmacol. 522 130. PMID: 16213481.
Venable et al (2005) Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine H4 antagonists. J.Med.Chem. 48 8289. PMID: 16366610.
Terzioglu et al (2004) Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists. Bioorg.Med.Chem.Lett. 14 5251. PMID: 15454206.
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Keywords: JNJ 10191584 maleate, supplier, Selective, H4, receptor, antagonists, orally, active, Receptors, Histamine, histaminergic, JNJ10191584, maleate, VUF6002, silent, antagonist, Tocris Bioscience, Histamine H4 Receptor Antagonist products
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