Cat. No. 2440
Chemical Name: 1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,
Biological ActivitySomatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Liu et al (1999) 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. Curr.Pharm.Des. 5 255. PMID: 10101224.
Liu et al (1998) Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J.Med.Chem. 41 4693. PMID: 9822540.
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Keywords: NNC 26-9100, supplier, Selective, sst4, agonists, Receptors, Somatostatin, NNC269100, Tocris Bioscience, Somatostatin (sst) Receptor Agonist products
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