2-Iodomelatonin

Cat. No. 0737

2-Iodomelatonin C13H15IN2O2 [93515-00-5]

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Chemical Name: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide

Biological Activity

Potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Technical Data

M.Wt:
358.18
Formula:
C13H15IN2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
93515-00-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.

Suiciak et al (1991) Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 11 2855. PMID: 1652626.

Dubocovich and Takahashi (1987) Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 84 3916. PMID: 3035559.

If you know of a relevant reference for 2-Iodomelatonin please let us know.

Citations are publications that use Tocris products. Selected citations for 2-Iodomelatonin include:

Calamini et al (2008) Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J 413 81. PMID: 18254726.

Nosjean et al (2000) Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 275 31311. PMID: 10913150.

Do you know of a great paper that uses 2-Iodomelatonin from Tocris? If so please let us know.

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Keywords: 2-Iodomelatonin, supplier, High, affinity, melatonin, agonists, MT, Receptors, Tocris Bioscience, Melatonin Receptor Agonist products

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