Curcumin

Cat. No. 2841

Curcumin C21H20O6 [458-37-7]

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Alternative Name: Diferuloylmethane

Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

Biological Activity

Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.

Technical Data

M.Wt:
368.38
Formula:
C21H20O6
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol
Storage:
Store at -20°C
CAS No:
458-37-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Aggarwal and Sung (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. TiPS 30 85. PMID: 19110321.

Cole et al (2007) Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 595 197. PMID: 17569212.

Kuttan et al (2007) Antitumour, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 595 173. PMID: 17569210.

Lin (2007) Molecular targets of curcumin. Adv.Exp.Med.Biol. 595 227. PMID: 17569214.

Miriyala et al (2007) Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 595 359. PMID: 17569220.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Curcumin include:

Efthymiou et al (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. J Neurosci 4 230. PMID: 25637190.

Do you know of a great paper that uses Curcumin from Tocris? If so please let us know.

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Keywords: Curcumin, supplier, Antitumor, anti-inflammatory, antioxidant, Apoptosis, Inducer, nrf2, Tocris Bioscience, Apoptosis Inducing products

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