Cat. No. 0932
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)piperidin
Biological ActivityPotent histamine H3 receptor agonist. Also binds to H4 receptors (Ki values are 0.4 and 9 nM at human recombinant H3 and H4 receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Liu et al (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59 420. PMID: 11179434.
Coruzzi et al (1995) Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat. Naunyn Schmiedebergs Arch.Pharmacol. 351 569. PMID: 7675114.
Vollinga et al (1994) A new potent and selective histamine H3 receptor agonist. J.Med.Chem. 37 332. PMID: 8308858.
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Citations are publications that use Tocris products. Selected citations for Immepip dihydrobromide include:
Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910. PMID: 12411423.
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Keywords: Immepip dihydrobromide, supplier, H4, H3, agonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H3 Receptor Agonist products
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