L-NIO dihydrochloride

Cat. No. 0546

L-NIO dihydrochloride C7H15N3O2.2HCl [159190-44-0]

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Chemical Name: N5-(1-Iminoethyl)-L-ornithine dihydrochloride

Biological Activity

Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.

Technical Data

Soluble to 100 mM in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Moncada et al (1997) XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 49 137. PMID: 9228663.

Mulligan et al (1992) Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 107 1159. PMID: 1281719.

Rees et al (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 101 746. PMID: 1706208.

If you know of a relevant reference for L-NIO dihydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for L-NIO dihydrochloride include:

Bergeron et al (2015) Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats. PLoS Negl Trop Dis 156 638. PMID: 25456068.

Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Insulin-Resistant Rats. Endocrinology 10 e0140762. PMID: 26485682.

Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20. PMID: 23419451.

Wu et al (2013) Vasorelaxin: a novel arterial smooth muscle-relaxing eicosapeptide from the skin secretion of the Chinese piebald odorous frog (Odorrana schmackeri). PLoS One 8 e55739. PMID: 23405205.

Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248. PMID: 21856924.

Do you know of a great paper that uses L-NIO dihydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: L-NIO dihydrochloride, supplier, Potent, eNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Endothelial, Synthase, NO, Synthases, Tocris Bioscience, eNOS Inhibitor products

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