Cat. No. 2436
Chemical Name: 4'-Octyl-[1,1'-biphenyl]-4-carboxylic
Biological ActivityPotent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lund et al (2009) Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands. J.Med.Chem. 52 1540. PMID: 19239230.
Lund et al (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 48 7517. PMID: 16302793.
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Citations are publications that use Tocris products. Selected citations for AC 55649 include:
Kang et al (2011) Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells. Front Behav Neurosci 4 66. PMID: 20664575.
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Keywords: AC 55649, supplier, Selective, RARβ, RARbeta2, agonists, RAMBA, Retinoic, Acid, Receptors, AC55649, Tocris Bioscience, Retinoic Acid Receptor Agonist products
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