Cat. No. 2436
Chemical Name: 4'-Octyl-[1,1'-biphenyl]-4-carboxylic
Biological ActivityPotent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lund et al (2009) Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands. J.Med.Chem. 52 1540. PMID: 19239230.
Lund et al (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 48 7517. PMID: 16302793.
If you know of a relevant reference for AC 55649 please let us know.
Citations are publications that use Tocris products. Selected citations for AC 55649 include:
Kelley (2017) Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells. PLoS One 12 (5) e0178116. PMID: 28552962.
Kang et al (2011) Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells. Front Behav Neurosci 4 66. PMID: 20664575.
Do you know of a great paper that uses AC 55649 from Tocris? If so please let us know.
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Keywords: AC 55649, supplier, Selective, RARβ, RARbeta2, agonists, RAMBA, Retinoic, Acid, Receptors, AC55649, Tocris Bioscience, Retinoic Acid Receptor Agonist products
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