Idazoxan hydrochloride

Cat. No. 0793

Idazoxan hydrochloride
 C11H12N2O2.HCl [79944-56-2]

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Alternative Name: RX 781094

Chemical Name: 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride

Biological Activity

α2-adrenoceptor antagonist, and I2 ligand, selective over I1 sites (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α2A, α2B, and α2C receptors respectively).

Technical Data

M.Wt:
240.69
Formula:
C11H12N2O2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
79944-56-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381. PMID: 9786027.

Berdeu et al (1995) Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 275 91. PMID: 7774667.

Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 13 369. PMID: 1413085.

Dabir (1986) Idazoxan: a novel pharmacological tool for the study of α2-adrenoceptors. J.Pharmacol. 17 113. PMID: 2875218.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Idazoxan hydrochloride include:

Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128. PMID: 24714037.

Do you know of a great paper that uses Idazoxan hydrochloride from Tocris? If so please let us know.

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Keywords: Idazoxan hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, antagonists, I2, ligand, Receptors, Imidazoline, RX781094, Tocris Bioscience, Adrenergic α2 Receptor Antagonist products

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