Cat. No. 1178
Biological ActivityPotent selective NK1 tachykinin receptor agonist.
(Modifications: X = Sar, Met-11 = Met(O2), Met-11 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cellier et al (1999) Characterisation of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br.J.Pharmacol. 127 717. PMID: 10401563.
Li and Zhao (1998) Small sensory neurons in the rat dorsal root ganglia express functional NK-1 tachykinin receptor. Eur.J.Neurosci. 10 1292. PMID: 9749783.
King et al (1997) Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro. Brain Res. 767 55. PMID: 9365015.
Tousignant et al (1990) 125I-BH[Sar9,Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system. Brain Res. 524 263. PMID: 1705465.
If you know of a relevant reference for [Sar9,Met(O2)11]-Substance P please let us know.
Citations are publications that use Tocris products. Selected citations for [Sar9,Met(O2)11]-Substance P include:
Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265. PMID: 23235155.
Do you know of a great paper that uses [Sar9,Met(O2)11]-Substance P from Tocris? If so please let us know.
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Keywords: [Sar9,Met(O2)11]-Substance P, supplier, Potent, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, [Sar9Met(O2)11]-SubstanceP, Tocris Bioscience, NK1 Receptor Agonist products
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July 8 - 12, 2017