Cat. No. 2432
Alternative Name: BL 4162A
Chemical Name: 6,7-Dichloro-1,5-dihydroimidazo[2,1
Biological ActivityPotent type III phosphodiesterase (PDE3) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wang et al (2005) Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br.J.Pharmacol. 146 324. PMID: 16041400.
Mazur et al (1992) Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 79 1931. PMID: 1562721.
Gillespie (1988) Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. Biochem.Pharmacol. 37 2866. PMID: 2456068.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Anagrelide hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Anagrelide hydrochloride, supplier, Potent, PDE3, inhibitors, inhibits, Phosphodiesterases, BL4162A, Tocris Bioscience, Phosphodiesterase Inhibitor products
Find multiple products by catalog number
New Products in this Area
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidantpCPA methyl ester hydrochloride
Tryptophan hydroxylase inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.