Anagrelide hydrochloride

Cat. No. 2432

Anagrelide hydrochloride C10H7Cl2N3O.HCl [58579-51-4]

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Alternative Name: BL 4162A

Chemical Name: 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride

Biological Activity

Potent type III phosphodiesterase (PDE3) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

Technical Data

M.Wt:
292.55
Formula:
C10H7Cl2N3O.HCl
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
58579-51-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Wang et al (2005) Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br.J.Pharmacol. 146 324. PMID: 16041400.

Mazur et al (1992) Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 79 1931. PMID: 1562721.

Gillespie (1988) Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. Biochem.Pharmacol. 37 2866. PMID: 2456068.

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Keywords: Anagrelide hydrochloride, supplier, Potent, PDE3, inhibitors, inhibits, Phosphodiesterases, BL4162A, Tocris Bioscience, Phosphodiesterase Inhibitor products

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