ARL 67156 trisodium salt
Cat. No. 1283
Alternative Name: FPL 67156
Chemical Name: 6-N,N-Diethyl-D-β,γ-dibromomethyleneA
Biological ActivitySelective NTPDase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Levesque et al (2007) Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ecotnucleotidases. Br.J.Pharmacol. 152 141. PMID: 17603550.
Kennedy et al (1997) Release of soluble nucleotidases: a novel mechanism for neurotransmitter inactivation? TiPS 18 263. PMID: 9277128.
Westfall et al (1997) The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea pig urinary bladder. Eur.J.Pharmacol. 329 169. PMID: 9226410.
Crack et al (1995) Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase. Br.J.Pharmacol. 114 475. PMID: 7533620.
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Citations are publications that use Tocris products. Selected citations for ARL 67156 trisodium salt include:
Fang et al (2016) Expression of CD39 on activated T cells impairs their survival in older individuals. Cell Rep. 14 1218. PMID: 26832412.
Boyd-Tressler et al (2014) Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism. J Biol Chem 289 27246. PMID: 25112874.
Campwala et al (2014) P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci 127 4964. PMID: 25271060.
Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60. PMID: 24926236.
Ziemlinska et al (2014) Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS One 9 e88833. PMID: 24551172.
Ashpole et al (2013) Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP. J Biol Chem 288 14599. PMID: 23543737.
Yegutkin et al (2012) Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J 26 3875. PMID: 22637533.
Griffiths et al (2011) Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. PLoS One 6 e23463. PMID: 21887254.
Kennedy et al (2007) Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci 27 845. PMID: 17251425.
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Keywords: ARL 67156 trisodium salt, supplier, Ecto-ATPase, inhibitors, inhibits, ARL67156, trisodium, salt, FPL67156, Tocris Bioscience, NTPDase Inhibitor products
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