ARL 67156 trisodium salt

Cat. No. 1283

ARL 67156 trisodium salt C15H21Br2N5O12P3.3Na [1021868-83-6]

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Alternative Name: FPL 67156

Chemical Name: 6-N,N-Diethyl-D-β,γ-dibromomethyleneATP trisodium salt

Biological Activity

Selective NTPDase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively).

Technical Data

M.Wt:
785.06
Formula:
C15H21Br2N5O12P3.3Na
Solubility:
Soluble to 20 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
1021868-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Levesque et al (2007) Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ecotnucleotidases. Br.J.Pharmacol. 152 141. PMID: 17603550.

Kennedy et al (1997) Release of soluble nucleotidases: a novel mechanism for neurotransmitter inactivation? TiPS 18 263. PMID: 9277128.

Westfall et al (1997) The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea pig urinary bladder. Eur.J.Pharmacol. 329 169. PMID: 9226410.

Crack et al (1995) Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase. Br.J.Pharmacol. 114 475. PMID: 7533620.

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Citations are publications that use Tocris products. Selected citations for ARL 67156 trisodium salt include:

Fang et al (2016) Expression of CD39 on activated T cells impairs their survival in older individuals. Cell Rep. 14 1218. PMID: 26832412.

Acton and Miles (2015) Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine. Sci Signal 10 e0134488. PMID: 26252389.

Billaud et al (2015) A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. J Neuroimmune Pharmacol 8 ra17. PMID: 25690012.

Boyd-Tressler et al (2014) Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism. J Biol Chem 289 27246. PMID: 25112874.

Campwala et al (2014) P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci 127 4964. PMID: 25271060.

Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60. PMID: 24926236.

Hennel et al (2014) Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated γ-irradiation. Proc Natl Acad Sci U S A 9 85. PMID: 24666643.

Sorrell and Hauser (2014) Ligand-gated purinergic receptors regulate HIV-1 Tat and morphine related neurotoxicity in primary mouse striatal neuron-glia co-cultures. Radiat Oncol 9 233. PMID: 24158495.

Ziemlinska et al (2014) Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS One 9 e88833. PMID: 24551172.

Ashpole et al (2013) Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP. J Biol Chem 288 14599. PMID: 23543737.

Jansen et al (2013) ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Sci Rep 110 20206. PMID: 24277820.

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. PLoS One 305 F396. PMID: 23720349.

Yegutkin et al (2012) Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J 26 3875. PMID: 22637533.

Griffiths et al (2011) Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. PLoS One 6 e23463. PMID: 21887254.

Kennedy et al (2007) Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci 27 845. PMID: 17251425.

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Keywords: ARL 67156 trisodium salt, supplier, Ecto-ATPase, inhibitors, inhibits, ARL67156, trisodium, salt, FPL67156, Tocris Bioscience, NTPDase Inhibitor products

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