ICI 199,441 hydrochloride
Cat. No. 0778
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[
Biological ActivityHighly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149. PMID: 1659636.
Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181. PMID: 1846918.
If you know of a relevant reference for ICI 199,441 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ICI 199,441 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: ICI 199,441 hydrochloride, supplier, Potent, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, ICI199441, hydrochloride, AstraZeneca, Tocris Bioscience, κ Opioid Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.