ICI 192,605

Cat. No. 0837

ICI 192,605
 C22H23ClO5 [117621-64-4]

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Chemical Name: 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid

Biological Activity

Potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619 (Cat. No. 1932).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
402.87
Formula:
C22H23ClO5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
117621-64-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cao et al (2004) Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity. Eur.J.Pharmacol. 485 317. PMID: 14757156.

Arakawa et al (1993) Leukotriene D4 and prostaglandin F2a- induced airflow obstruction and airway plasma exudation in guinea pig: role of thromboxane and its receptor. Br.J.Pharmacol. 110 127. PMID: 8220872.

Brewster et al (1988) The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid ICI 192605. Prostaglandins 36 173. PMID: 2973084.

If you know of a relevant reference for ICI 192,605 please let us know.

Citations are publications that use Tocris products. Selected citations for ICI 192,605 include:

Daray et al (2003) Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein. Naunyn Schmiedebergs Arch Pharmacol 139 1409. PMID: 12922927.

Do you know of a great paper that uses ICI 192,605 from Tocris? If so please let us know.

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Keywords: ICI 192,605, supplier, Potent, thromboxane, A2, TXA2, TP, receptor, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI192605, AstraZeneca, Tocris Bioscience, Prostanoid Receptor Antagonist products

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