ICI 174,864

Cat. No. 0820

ICI 174,864
 N,N-diallyl-Tyr-Aib-Aib-Phe-Leu

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Biological Activity

Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
691.87
Formula:
C38H53N5O7
Sequence:
YXXFL

(Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)

Solubility:
Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
89352-67-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769. PMID: 2875170.

Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311. PMID: 2987731.

Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383. PMID: 2987739.

Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331. PMID: 6323195.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ICI 174,864 include:

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086. PMID: 18703511.

Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556. PMID: 10516632.

Do you know of a great paper that uses ICI 174,864 from Tocris? If so please let us know.

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Keywords: ICI 174,864, supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Tocris Bioscience, δ Opioid Receptor Antagonist products

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