Cat. No. 0820
Biological ActivitySelective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
(Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769. PMID: 2875170.
Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311. PMID: 2987731.
Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383. PMID: 2987739.
Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331. PMID: 6323195.
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Citations are publications that use Tocris products. Selected citations for ICI 174,864 include:
Gallego et al (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol 18 737. PMID: 18803462.
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086. PMID: 18703511.
Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556. PMID: 10516632.
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Keywords: ICI 174,864, supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Tocris Bioscience, δ Opioid Receptor Antagonist products
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