LP 12 hydrochloride

Cat. No. 2925

LP 12 hydrochloride C32H39N3O.HCl [1185136-22-4]

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Chemical Name: 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide hydrochloride

Biological Activity

5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.22, 7.3, 52.7 and 326 nM respectively). Induces relaxation of substance P-induced contractions in guinea pig ileum (EC50 = 1.77 μM).

Licensing Information

Sold under license from the University of Bari

Technical Data

M.Wt:
518.13
Formula:
C32H39N3O.HCl
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1185136-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Leopoldo et al (2007) Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J.Med.Chem. 50 4214. PMID: 17649988.

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Keywords: LP 12 hydrochloride, supplier, 5-HT7, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, LP12, hydrochloride, Tocris Bioscience, 5-HT7 Receptor Agonist products

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