Cat. No. 0832
Chemical Name: N-[2-[3-(2-Cyanophenoxy)-2-hydroxyp
Biological Activityβ-adrenergic antagonist and low efficacy partial agonist; does not affect resting cardiac parameters.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mai (1990) β-Adrenergic Receptors. Comprehensive Medicinal Chemistry. Ed. Hansch. 3 187.
If you know of a relevant reference for ICI 89406 please let us know.
Citations are publications that use Tocris products. Selected citations for ICI 89406 include:
Mistry et al (2013) Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. J Med Chem 56 3852. PMID: 23614528.
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Pharmacol Exp Ther 329 350. PMID: 19144685.
Do you know of a great paper that uses ICI 89406 from Tocris? If so please let us know.
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