2-Hydroxysaclofen

Cat. No. 0245

2-Hydroxysaclofen C9H12ClNO4S [117354-64-0]

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Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid

Biological Activity

Selective antagonist at GABAB receptors.

Technical Data

M.Wt:
265.71
Formula:
C9H12ClNO4S
Solubility:
Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
Storage:
Store at RT
CAS No:
117354-64-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Curtis et al (1988) Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord. Neurosci.Lett. 92 97. PMID: 2847093.

Kerr et al (1988) 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABAB receptors. Neurosci.Lett. 92 92. PMID: 2847092.

If you know of a relevant reference for 2-Hydroxysaclofen please let us know.

Citations are publications that use Tocris products. Selected citations for 2-Hydroxysaclofen include:

Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Nature 101 2151. PMID: 14766975.

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038. PMID: 15210585.

Do you know of a great paper that uses 2-Hydroxysaclofen from Tocris? If so please let us know.

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Keywords: 2-Hydroxysaclofen, supplier, Selective, GABAB, antagonists, Receptors, Tocris Bioscience, GABAB Receptor Antagonist products

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