GGTI 298

Cat. No. 2430

GGTI 298 C27H33N3O3S.CF3CO2H [1217457-86-7]

Price and Availability

For GGTI 298 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt

Biological Activity

CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

Technical Data

Soluble to 25 mM in DMSO
>95 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
Select another batch:

References are publications that support the products' biological activity.

Porcu et al (2010) A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics. Mol.Cancer 9 197. PMID: 20653956.

Kusama et al (2003) Selective inhibition of cancer cell invasion by a geranylgeranyltransferase inhibitor. Clin.Exp.Meta. 20 561.

Miquel et al (1997) GGTI-298 induces G0-G1 block and apoptosis whereas FTI-227 causes G2-M enrichment in A549 cells. Cancer Res. 57 1846. PMID: 9157972.

McGuire et al (1996) Platelet-derived growth factor receptor tyrosine kinase phosphorylation requires protein geranylgeranylation but not farnesylation. J.Biol.Chem. 271 27402. PMID: 8910319.

If you know of a relevant reference for GGTI 298 please let us know.

Citations are publications that use Tocris products. Selected citations for GGTI 298 include:

Domingue et al (2016) Chenodeoxycholic Acid Requires Activation of EGFR, EPAC and Ca2+ to Stimulate CFTR-dependent Cl-Secretion in Human Colonic T84 Cells. American Journal of Physiology - Cell Physiology. PMID: 27558159.

Do you know of a great paper that uses GGTI 298 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: GGTI 298, supplier, GGTI298, geranylgeranyltransferase, GGTase1, Tocris Bioscience, Protein Prenyltransferase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area

BRD 4770

G9a inhibitor and S-adenosyl methionine mimetic; cell permeable


Selective p300 inhibitor

UNC 2399

Biotinylated UNC 1999 (Cat.No. 4904)

PF 06726304 acetate

Highly potent and SAM-competitive EZH2 inhibitor

GSK 591 dihydrochloride

Potent and selective PRMT5 inhibitor

TP 064

Potent and selective PRMT 4 inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11