Fexofenadine hydrochloride

Cat. No. 2429

Fexofenadine hydrochloride C32H39NO4.HCl [153439-40-8]

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Alternative Names: MDL 16455, Terfenidine

Chemical Name: α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneacetic acid hydrochloride

Biological Activity

Selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects.

Technical Data

Soluble to 50 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gillard and Chatelaine (2006) Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. Eur.J.Pharmacol. 530 205. PMID: 16388798.

Sakairi et al (2005) Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 75 76. PMID: 16037679.

Markham and Wagstaff (1998) Fexofenadine. Drugs 55 269. PMID: 9506246.

If you know of a relevant reference for Fexofenadine hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Fexofenadine hydrochloride include:

Won et al (2013) A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo "connect". Mucosal Immunol 53 982. PMID: 23878024.

Do you know of a great paper that uses Fexofenadine hydrochloride from Tocris? If so please let us know.

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Keywords: Fexofenadine hydrochloride, supplier, H1, receptor, antagonists, non-sedating, antiallergic, agent, Receptors, Histamine, histaminergic, MDL16455, Tocris Bioscience, Histamine H1 Receptor Antagonist products

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