DAPTA

Cat. No. 2423

DAPTA D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2

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Alternative Name: D-Ala-peptide T-amide

Biological Activity

Chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.

Technical Data

M.Wt:
856.89
Formula:
C35H56N10O15
Sequence:
ASTTTNYT

(Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
106362-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Polianova et al (2005) Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 67 83. PMID: 16002156.

Rosi et al (2005) Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 134 671. PMID: 15979806.

Ruff et al (2003) Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 1 51. PMID: 15043212.

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Keywords: DAPTA, supplier, Chemokine, receptor, 5, CCR5, antagonists, CXCR, Receptors, antiviral, Rantes, Tocris Bioscience, Chemokine CC Receptor Antagonist products

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