Cat. No. 2420
Alternative Name: [pGlu1]-Apelin-13
Biological ActivityHighly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.
(Modifications: X = Glp)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kagiyama et al (2005) Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 125 55. PMID: 15582714.
Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198. PMID: 15907343.
Katugampola et al (2001) [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 132 1255. PMID: 11250876.
Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471.
If you know of a relevant reference for [Pyr1]-Apelin-13 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses [Pyr1]-Apelin-13 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: [Pyr1]-Apelin-13, supplier, Potent, peptide, agonists, APJ, Receptors, Apelin, adipokines, Tocris Bioscience, Apelin Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Negative control for ELA-14 (Cat.No. 6293)ELA-14 (human)
Potent apelin (APJ) receptor agonistRetrobradykinin
Reverse analog of BradykininTASP 0390325
Potent and selective V1B receptor antagonist; orally bioavailableML 233
Non-peptide apelin receptor agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.