Cat. No. 2418
Chemical Name: 2-(1-Piperazinyl)-8-phenyl-4H-1-ben
Biological ActivityNegative control compound with respect to LY 294002 (Cat. No. 1130) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kristof et al (2005) LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J.Pharmacol.Exp.Ther. 314 1134. PMID: 15923340.
Choi et al (2004) LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Letters. 559 141. PMID: 14960322.
El-kholy et al (2003) The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks KV currents via a direct mechanism. FASEB J. 17 720. PMID: 12586735.
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Keywords: LY 303511, supplier, Negative, control, LY, 294002, LY294002, PI3K, Phosphoinositide, PI, 3-Kinases, PIP2, Inositol, Lipids, LY303511, Tocris Bioscience, PI 3-kinase Inhibitor products
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