BIBU 1361 dihydrochloride
Cat. No. 2417
Chemical Name: N-(3-Chloro-4-fluorophenyl)-6-[4-[(
Biological ActivityPotent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC50 > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Solca et al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502. PMID: 15199094.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses BIBU 1361 dihydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: BIBU 1361 dihydrochloride, supplier, Selective, inhibitors, inhibits, EGFR-kinases, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, BIBU1361, dihydrochloride, Tocris Bioscience, EGFR Inhibitor products