HA 1100 hydrochloride
Cat. No. 2415
Alternative Name: Hydroxyfasudil
Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolin
Biological ActivityCell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Utsunomiya et al (2001) Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br.J.Pharmacol. 134 1724. PMID: 11739249.
Shimokawa et al (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc.Res. 43 1029. PMID: 10615430.
Arai et al (1993) Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487. PMID: 8240400.
If you know of a relevant reference for HA 1100 hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:
Pearn et al (2012) Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology 116 352. PMID: 22198221.
Do you know of a great paper that uses HA 1100 hydrochloride from Tocris? If so please let us know.
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