HA 1100 hydrochloride

Cat. No. 2415

HA 1100 hydrochloride C14H17N3O3S.HCl [155558-32-0]

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Alternative Name: Hydroxyfasudil

Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.

Technical Data

M.Wt:
343.83
Formula:
C14H17N3O3S.HCl
Solubility:
Soluble to 20 mM in water
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
155558-32-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Utsunomiya et al (2001) Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br.J.Pharmacol. 134 1724. PMID: 11739249.

Shimokawa et al (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc.Res. 43 1029. PMID: 10615430.

Arai et al (1993) Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487. PMID: 8240400.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:

Pearn et al (2012) Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology 116 352. PMID: 22198221.

Do you know of a great paper that uses HA 1100 hydrochloride from Tocris? If so please let us know.

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Keywords: HA 1100 hydrochloride, supplier, Cell-permeable, selective, Rho-kinase, inhibitors, inhibits, Rho-Associated, Coiled-Coil, Kinases, p160ROCK, ROK, Rho-Kinase, HA1100, hydrochloride, Tocris Bioscience, Rho-Kinases Inhibitor products

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