Cat. No. 2687
Alternative Name: PTZ
Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5
Biological ActivityCNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dhir et al (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat. 30 1478.
Walsh et al (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 289 1626. PMID: 10336561.
Rocha et al (1996) Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 26 105. PMID: 8985692.
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Keywords: Pentylenetetrazole, supplier, CNS, stimulant, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, GABAB, GABAA, GABAC, Tocris Bioscience, Miscellaneous GABA products