A-71623

Cat. No. 2411

A-71623 Boc-Trp-Lys(Tac)-Asp-N-methyl-Phe-NH2

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Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide

Biological Activity

Potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.

Technical Data

M.Wt:
840.97
Formula:
C44H56N8O9
Sequence:
XWKDF

(Modifications: Trp-1 = Boc-Trp, Lys-3 = Lys(Tac), Phe-5 = N-methyl-Phe & C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 20mM PBS buffer
Storage:
Desiccate at -20°C
CAS No:
130408-77-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699. PMID: 1513850.

DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951.

Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346.

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Keywords: A-71623, supplier, Potent, selective, CCK1, agonists, Suppresses, feeding, Cholecystokinin1, Receptors, A71623, Tocris Bioscience, CCK1 Receptor Agonist products

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