Cat. No. 2688
Alternative Names: Irinotecan, Camptothecin 11
Chemical Name: (4S)-4,11-Diethyl-3,4,12,14-tetrahy
Biological ActivityInhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Morton et al (2005) Activation and antitumour activity of CPT-11 in plasma esterase-deficient mice. Can.Chemother.Pharmacol. 56 629.
Vassal et al (1996) Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br.J.Cancer. 74 537. PMID: 8761367.
Kawato et al (1993) Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. J.Pharm.Pharmacol. 45 444. PMID: 8099964.
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Citations are publications that use Tocris products.
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Keywords: CPT 11, supplier, DNA, topoisomerase, I, inhibitors, inhibits, antitumor, Isomerases, CPT11, Camptothecin11, chemotherapeutics, Tocris Bioscience, DNA Topoisomerase Inhibitor products
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