RJR 2429 dihydrochloride
Cat. No. 1271
Chemical Name: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2
Biological ActivityPotent nAChR agonist that displays selectivity for α4β2 (Ki = 1 nM) and α1βγδ subtypes (EC50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bhatti et al (2008) Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. J.Org.Chem. 73 3497. PMID: 18363376.
Yokotani et al (2002) Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from isolated rat adrenal gland. Eur.J.Pharmacol. 446 83. PMID: 12098588.
Bencherif et al (1998) The heterocyclic substituted pyridine derivative (±)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 284 886. PMID: 9495846.
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Keywords: RJR 2429 dihydrochloride, supplier, Nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, RJR2429, dihydrochloride, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonist products
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Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
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