Conessine

Cat. No. 2409

Conessine C24H40N2 [546-06-5]

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Chemical Name: N,N-Dimethyl-con-5-enin-3-amine

Biological Activity

Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).

Technical Data

M.Wt:
356.59
Formula:
C24H40N2
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO with gentle warming
Storage:
Store at RT
CAS No:
546-06-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Zhao et al (2008) The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J.Med.Chem. 51 5423. PMID: 18683917.

Witte et al (2005) Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist. Soc.Neurosci.Abstr. 491 19.

Zirihi et al (2005) Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorg.Med.Chem.Lett. 15 2637. PMID: 15863333.

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Keywords: Conessine, supplier, Potent, selective, H3, receptor, antagonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H3 Receptor Antagonist products

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