Cat. No. 1269
Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-p
Biological ActivitySelective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311. PMID: 9989777.
Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177. PMID: 9399991.
Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687. PMID: 8692879.
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Citations are publications that use Tocris products. Selected citations for PD 150606 include:
Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. PLoS One 6 9173. PMID: 25823819.
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Keywords: PD 150606, supplier, PD150606, calpain, inhibitors, inhibits, selective, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Tocris Bioscience, Calpain Inhibitor products
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