MRS 3777 hemioxalate
Cat. No. 2403
Chemical Name: 2-Phenoxy-6-(cyclohexylamino)purine
Biological ActivityHigh affinity adenosine A3 receptor antagonist (Ki = 47 nM) that displays > 200-fold selectivity versus A1, A2A and A2B receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247. PMID: 16518376.
Moro et al (2006) Progress in the pursuit of therapeutic adenosine receptor antagonists. Med.Res.Rev. 26 131. PMID: 16380972.
Perreira et al (2005) "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J.Med.Chem. 48 4910. PMID: 16033270.
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Citations are publications that use Tocris products. Selected citations for MRS 3777 hemioxalate include:
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Nature 14 201. PMID: 26597723.
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Keywords: MRS 3777 hemioxalate, supplier, High, affinity, selective, A3, antagonists, Receptors, adenosines, MRS3777, hemioxalate, Tocris Bioscience, Adenosine A3 Receptor Antagonist products