Cat. No. 2397

Eplerenone C24H30O6 [107724-20-9]

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Alternative Names: Inspra, Epoxymexrenone

Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester

Biological Activity

Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.

Technical Data

Soluble to 10 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190. PMID: 11714095.

De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650. PMID: 2949071.

If you know of a relevant reference for Eplerenone please let us know.

Citations are publications that use Tocris products. Selected citations for Eplerenone include:

Urbanet et al (2010) Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. Purinergic Signal 95 4037. PMID: 20484481.

Do you know of a great paper that uses Eplerenone from Tocris? If so please let us know.

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Keywords: Eplerenone, supplier, Selective, mineralocorticoid, receptor, antagonists, Aldosterone, Receptors, Tocris Bioscience, Mineralocorticoid Receptor Antagonist products

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