Cat. No. 2397
Alternative Names: Inspra, Epoxymexrenone
Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-o
Biological ActivitySelective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190. PMID: 11714095.
De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650. PMID: 2949071.
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Citations are publications that use Tocris products. Selected citations for Eplerenone include:
Urbanet et al (2010) Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. Purinergic Signal 95 4037. PMID: 20484481.
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Keywords: Eplerenone, supplier, Selective, mineralocorticoid, receptor, antagonists, Aldosterone, Receptors, Tocris Bioscience, Mineralocorticoid Receptor Antagonist products
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