Glimepiride

Cat. No. 2396

Glimepiride C24H34N4O5S [93479-97-1]

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Alternative Names: Amaryl, Glimperide

Chemical Name: 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide

Biological Activity

Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Technical Data

M.Wt:
490.62
Formula:
C24H34N4O5S
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
93479-97-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Lawrence et al (2002) Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sacrolemmal KATP channels. Br.J.Pharmacol. 136 746. PMID: 12086984.

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Keywords: Glimepiride, supplier, KATP, channels, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blocker products

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