Cat. No. 2395
Chemical Name: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,
Biological ActivityPotent, orally active selective serotonin re-uptake inhibitor (SSRI); antidepressant.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Doogan and Caillard (1988) Sertraline: a new antidepressant. J.Clin.Psychiatry. 49 46.
Heym and Koe (1988) Pharmacology of sertraline: a review. J.Clin.Psychiatry 49 40. PMID: 3045112.
Koe et al (1983) Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J.Pharmacol.Exp.Ther. 226 686. PMID: 6310078.
If you know of a relevant reference for Sertraline hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for Sertraline hydrochloride include:
Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392. PMID: 27413150.
Pai et al (2015) Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci 35 4366. PMID: 25762681.
Do you know of a great paper that uses Sertraline hydrochloride from Tocris? If so please let us know.
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Keywords: Sertraline hydrochloride, supplier, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Pfizer, ssri, Tocris Bioscience, 5-HT Transporter Inhibitor products