Homoharringtonine

Cat. No. 1416

Homoharringtonine C29H39NO9 [26833-87-4]

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Chemical Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate

Biological Activity

Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic.

Technical Data

M.Wt:
545.63
Formula:
C29H39NO9
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
26833-87-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cai et al (2001) Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 15 567. PMID: 11368358.

Zhou et al (1995) Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 82 987. PMID: 8745664.

Fresno et al (1977) Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 72 323. PMID: 319998.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Homoharringtonine include:

Akef et al (2015) Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. Cell J 21 1908. PMID: 26362019.

Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638. PMID: 23792643.

Do you know of a great paper that uses Homoharringtonine from Tocris? If so please let us know.

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Keywords: Homoharringtonine, supplier, inhibitors, inhibits, protein, synthesis, Antileukemic, agent, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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