1400W dihydrochloride

Cat. No. 1415

1400W dihydrochloride C10H15N3.2HCl [214358-33-5]

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Chemical Name: N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride

Biological Activity

Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo.

Technical Data

M.Wt:
250.17
Formula:
C10H15N3.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
214358-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Parmentier et al (1999) Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br.J.Pharmacol. 127 546. PMID: 10385257.

Garvey et al (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J.Biol.Chem. 272 4959. PMID: 9030556.

Thomsen et al (1997) Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res. 57 3300. PMID: 9242464.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 1400W dihydrochloride include:

Clark et al (2015) Selective activation of microglia facilitates synaptic strength. RNA 35 4552. PMID: 25788673.

Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20. PMID: 23419451.

Gresa-Arribas et al (2012) Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents. PLoS One 7 e45227. PMID: 23028862.

Al-Shalmani et al (2011) Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery. Br J Pharmacol 162 1485. PMID: 21375526.

Tsuda et al (2009) Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. J Cell Mol Med 13 3251. PMID: 19298529.

Do you know of a great paper that uses 1400W dihydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 1400W dihydrochloride, supplier, Potent, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, Tocris Bioscience, iNOS Inhibitor products

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