trans-4-Hydroxycrotonic acid

Cat. No. 0538

trans-4-Hydroxycrotonic acid C4H6O3 [24587-49-3]

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Chemical Name: trans-4-Hydroxy-2-butenoic acid

Biological Activity

Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself.  May be an endogenous ligand.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hechler et al (1993) Gamma hydroxybutyrate ligands posses antidopaminergic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 264 1406. PMID: 8095552.

Bourguignon et al (1988) Analogues of γ-hydroxybutyric acid. Synthesis and binding studies. J.Med.Chem. 31 893. PMID: 3361576.

Vayer et al (1985) Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 34 2401. PMID: 4015683.

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Citations are publications that use Tocris products.

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Keywords: trans-4-Hydroxycrotonic acid, supplier, GHB, receptor, ligand, GABAB, Receptors, GABAA, GABAC, Tocris Bioscience, Miscellaneous GABA products

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