L-(-)-threo-3-Hydroxyaspartic acid

Cat. No. 0183

L-(-)-threo-3-Hydroxyaspartic acid C4H7NO5 [7298-99-9]

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Alternative Name: L-threo-β-Hydroxyaspartic acid

Biological Activity

Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.

Technical Data

M.Wt:
149.1
Formula:
C4H7NO5
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>97 %
Storage:
Store at RT
CAS No:
7298-99-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Nakamura et al (1993) (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833. PMID: 7901789.

McBean and Roberts (1985) Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J.Neurochem. 44 247. PMID: 2856883.

Johnston et al (1980) Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. J.Neurochem. 34 241. PMID: 7452241.

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Keywords: L-(-)-threo-3-Hydroxyaspartic acid, supplier, potent, competitive, Transportable, EAAT1, EAAT2, EAAT3, EAAT4, EAAT1-4, inhibitors, inhibits, non-transportable, EAAT5, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, reuptake, L-threo-beta-Hydroxyaspartic, acid, Tocris Bioscience, Glutamate Transporter Inhibitor products

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