Ac-RYYRWK-NH2

Cat. No. 1387

Ac-RYYRWK-NH2 Ac-Arg-Tyr-Tyr-Arg-Trp-Lys-NH2

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Biological Activity

Potent, selective partial agonist peptide for the NOP receptor (Ki = 0.71 nM). Selective over μ, δ and κ opioid receptors (IC50 > 4000 nM). Increases food intake in vivo.

Technical Data

M.Wt:
1012.17
Formula:
C49H69N15O9
Sequence:
RYYRWK

(Modifications: Arg-1 = C-terminal Ac, Lys-6 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
200959-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ho et al (2000) Characterization of the ORL1 receptor on adrenergic nerve in the rat anococcygeus. Br.J.Pharmacol. 131 349. PMID: 10991930.

Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735. PMID: 9353393.

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Citations are publications that use Tocris products.

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Keywords: Ac-RYYRWK-NH2, supplier, Potent, selective, NOP, partial, agonists, peptide, Nociceptin, Receptors, ORL1, OP4, Opioid, Tocris Bioscience, NOP Receptor Agonist products

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