Cat. No. 0646
Alternative Name: Histamine trifluoromethyl toluidide
Chemical Name: 6-[2-(4-Imidazolyl)ethylamino]-N-(4
Biological ActivityH1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Shahid et al (2009) Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9.
Khan et al (1987) Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 30 2115. PMID: 2959777.
Khan et al (1986) The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 137 308. PMID: 3011908.
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Keywords: HTMT dimaleate, supplier, H2, H1, agonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H1 Receptor Agonist products