HTMT dimaleate

Cat. No. 0646

HTMT dimaleate C19H25F3N4O.2C4H4O4

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Alternative Name: Histamine trifluoromethyl toluidide

Chemical Name: 6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate

Biological Activity

H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.

Technical Data

Soluble to 100 mM in water
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Shahid et al (2009) Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9.

Khan et al (1987) Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 30 2115. PMID: 2959777.

Khan et al (1986) The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 137 308. PMID: 3011908.

If you know of a relevant reference for HTMT dimaleate please let us know.

Citations are publications that use Tocris products. Selected citations for HTMT dimaleate include:

Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. Br J Ophthalmol 30 582. PMID: 21139565.

Tripathi et al (2011) The Influence of histamine H1-receptor on liver functions in immunized rabbits. EMBO J 18 411. PMID: 23961154.

Do you know of a great paper that uses HTMT dimaleate from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: HTMT dimaleate, supplier, H2, H1, agonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H1 Receptor Agonist products

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