LY 456236 hydrochloride

Cat. No. 2390

LY 456236 hydrochloride C16H15N3O2.HCl [338736-46-2]

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Alternative Name: MPMQ hydrochloride

Chemical Name: 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride

Biological Activity

Selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively.

Technical Data

M.Wt:
317.77
Formula:
C16H15N3O2.HCl
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
338736-46-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bertorelli et al (2005) Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects. Neuropharmacology 49 (Suppl. 1) 231.

Shannon et al (2005) Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology 49 (Suppl. 1) 188. PMID: 16011839.

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Citations are publications that use Tocris products.

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Keywords: LY 456236 hydrochloride, supplier, Selective, mGlu1, mGluR1, antagonists, mGlur, Group, I, Receptors, Glutamate, Metabotropic, LY456236, hydrochloride, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products

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