AMN 082 dihydrochloride

Cat. No. 2385

AMN 082 dihydrochloride C28H28N2.2HCl [97075-46-2]

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Chemical Name: N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride

Biological Activity

The first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.

Technical Data

M.Wt:
465.45
Formula:
C28H28N2.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 2 mM in water with gentle warming
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
97075-46-2

Resources

Other Information

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Greco et al (2010) Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 332 1064. PMID: 19940105.

Flor et al (2005) AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo. Neuropharmacology 49 (Suppl. 1) 244.

Mitsukawa et al (2005) A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc.Natl.Acad.Sci.USA 102 18712.

If you know of a relevant reference for AMN 082 dihydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for AMN 082 dihydrochloride include:

Broadstock et al (2012) Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol 165 1034. PMID: 21627638.

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Keywords: AMN 082 dihydrochloride, supplier, selective, mGlu7, mGluR7, agonists, mGlur, Group, III, Receptors, Glutamate, Metabotropic, AMN082, dihydrochloride, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Agonist products

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