CB 13

Cat. No. 2928

CB 13 C26H24O2 [432047-72-8]

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Chemical Name: 1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone

Biological Activity

Potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC50 values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.

Technical Data

M.Wt:
368.47
Formula:
C26H24O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
432047-72-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cluny et al (2010) Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice. J.Pharmacol.Exp.Ther. 334 973. PMID: 20571060.

Dziadulewicz et al (2007) Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J.Med.Chem. 50 3851. PMID: 17630726.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CB 13 include:

Alvarez-Fuentes et al (2012) Development and validation of an RP-HPLC method for CB13 evaluation in several PLGA nanoparticle systems. ScientificWorldJournal 2012 737526. PMID: 22792051.

Do you know of a great paper that uses CB 13 from Tocris? If so please let us know.

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Keywords: CB 13, supplier, Potent, dual, CB1/CB2, agonists, cannabinoids, Non-Selective, Receptors, CB13, cb2r, cb1r, Tocris Bioscience, Non-selective Cannabinoid Agonist products

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