EMD 386088 hydrochloride
Cat. No. 2382
Chemical Name: 5-Chloro-2-methyl-3-(1,2,3,6-tetrah
Biological ActivityPotent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mattsson et al (2005) 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg.Med.Chem.Lett. 15 4230. PMID: 16055331.
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Citations are publications that use Tocris products. Selected citations for EMD 386088 hydrochloride include:
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79. PMID: 28300552.
Riccio et al (2011) Excess of serotonin affects neocortical pyramidal neuron migration. Transl Psychiatry 1 e47. PMID: 22833193.
Do you know of a great paper that uses EMD 386088 hydrochloride from Tocris? If so please let us know.
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