EMD 386088 hydrochloride

Cat. No. 2382

EMD 386088 hydrochloride C14H15N2Cl.HCl [1171123-46-8]

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Chemical Name: 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride

Biological Activity

Potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM).

Technical Data

M.Wt:
283.2
Formula:
C14H15N2Cl.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1171123-46-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mattsson et al (2005) 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg.Med.Chem.Lett. 15 4230. PMID: 16055331.

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Citations are publications that use Tocris products. Selected citations for EMD 386088 hydrochloride include:

Riccio et al (2011) Excess of serotonin affects neocortical pyramidal neuron migration. Transl Psychiatry 1 e47. PMID: 22833193.

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