ABT 702 dihydrochloride

Cat. No. 2372

ABT 702 dihydrochloride C22H19N6OBr.2HCl [1188890-28-9]

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Chemical Name: 5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine dihydrochloride

Biological Activity

Potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

Technical Data

M.Wt:
536.26
Formula:
C22H19N6OBr.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1188890-28-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lee et al (2001) Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem. 44 2133. PMID: 11405650.

Jarvis et al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive effects in the mouse. J.Pharmacol.Exp.Ther. 295 1156. PMID: 11082453.

Kowaluk et al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther. 295 1165. PMID: 11082454.

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Citations are publications that use Tocris products. Selected citations for ABT 702 dihydrochloride include:

Fassett et al (2011) Adenosine kinase regulation of cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol 300 H1722. PMID: 21335462.

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Keywords: ABT 702 dihydrochloride, supplier, adenosines, kinases, inhibitors, inhibits, orally, active, ADK, Receptors, ABT702, dihydrochloride, Tocris Bioscience, Adeonsine Kinase Inhibitor products

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