Cat. No. 1265
Alternative Names: Midafotel, SDZ EAA 494
Chemical Name: D-4-[(2E)-3-Phosphono-2-propenyl]-2
Biological ActivityPotent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Potschka et al (1999) Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats. Eur.J.Pharmacol. 374 175. PMID: 10422758.
Lowe et al (1990) D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci.Lett. 113 315. PMID: 2166255.
Aebischer et al (1989) Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene). Helv.Chim.Acta 72 1043.
If you know of a relevant reference for D-CPP-ene please let us know.
Citations are publications that use Tocris products. Selected citations for D-CPP-ene include:
Campos and Ritter (2015) NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation. Oncogene 308 R1. PMID: 25394828.
Do you know of a great paper that uses D-CPP-ene from Tocris? If so please let us know.
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Keywords: D-CPP-ene, supplier, Potent, competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, SDZEAA494, Tocris Bioscience, NMDA Receptor Antagonist products
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