Dihydro-β-erythroidine hydrobromide

Cat. No. 2349

Dihydro-b-erythroidine hydrobromide C16H21NO3.HBr [29734-68-7]

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Alternative Name: DHβE

Chemical Name: (2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide

Biological Activity

Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo.

Technical Data

M.Wt:
356.26
Formula:
C16H21NO3.HBr
Solubility:
Soluble to 100 mM in water and to 25 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
29734-68-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Harvey et al (1996) Multiple determinants of dihydro-β-erythroidine sensitivity on rat neuronal nicotinic receptor #945; subunits. J.Neurochem. 67 1953. PMID: 8863500.

Damaj et al (1995) In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice. Psychopharmacology 117 67. PMID: 7724704.

Williams and Robinson (1984) Binding of the nicotinic cholinergic antagonist, dihydro-β-erythroidine, to rat brain tissue. J.Neurosci. 4 2906. PMID: 6502210.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Dihydro-β-erythroidine hydrobromide include:

Kunisawa et al (2016) Nicotine evokes kinetic tremor by activating the inferior olive via α7 nicotinic acetylcholine receptors. Behav.Brain Res. 314 173. PMID: 27506652.

Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268. PMID: 27383600.

Bader and Diener (2015) Novel aspects of cholinergic regulation of colonic ion transport. Elife 3 e00139. PMID: 26236483.

Dilger et al (2015) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci 35 3652. PMID: 25716863.

Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. PLoS One 9 6. PMID: 25709566.

Morrie and Feller (2015) An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina. Neuroscience 35 9281. PMID: 26109653.

Ngolab et al (2015) Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. J Neurosci 35 8570. PMID: 26041923.

Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. J Neurosci 4. PMID: 25723967.

Stouffer et al (2015) Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543. PMID: 26503322.

Yorgason et al (2015) Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors. Front Cell Neurosci 284 854. PMID: 25451295.

Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538. PMID: 25303328.

Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Pharmacol Res Perspect 8 e82719. PMID: 24349346.

Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285. PMID: 22368777.

Goddard et al (2012) Gamma oscillations are generated locally in an attention-related midbrain network. Neuron 73 567. PMID: 22325207.

Platt et al (2012) Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. PLoS One 7 e36397. PMID: 22570709.

Li et al (2010) Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci 154 14. PMID: 19887306.

Li et al (2009) Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett 462 20. PMID: 19573576.

Do you know of a great paper that uses Dihydro-β-erythroidine hydrobromide from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Dihydro-b-erythroidine hydrobromide, supplier, antagonists, neuronal, alpha4-containing, nicotinic, receptors, α4β2, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, Non-Selective, Subtypes, Other, Dihydro-beta-erythroidine, hydrobromide, Dihydro-β-erythroidine, hydrobromide, DHβE, Tocris Bioscience, Nicotinic Receptor (Other Subtype) Antagonist products

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