HEAT hydrochloride

Cat. No. 0535

HEAT hydrochloride C19H21NO2.HCl [30007-39-7]

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Alternative Name: BE 2254

Chemical Name: 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride

Biological Activity

Very selective α1-adrenoceptor antagonist, precursor of the 3-[125I]-derivative.

Technical Data

M.Wt:
331.84
Formula:
C19H21NO2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
30007-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Williams et al (1978) Interaction of 2-[β-(4-hydroxyphenyl)ethylaminomethyl]tetralone (BE 2254: 'HEAT') with catecholamine receptors in rat brain membranes. J.Pharm.Pharmacol. 30 390. PMID: 26778.

Baumgarten et al (1972) Mechanisms of pressor effect of 5,6-dihydroxytryptamine in pithed rats. Naunyn Schmiedebergs Arch.Pharmacol. 274 375. PMID: 4404780.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for HEAT hydrochloride include:

Grisanti et al (2011) α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther 338 648. PMID: 21571945.

Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Circ Res 24 7745. PMID: 15342742.

Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029. PMID: 11805341.

Do you know of a great paper that uses HEAT hydrochloride from Tocris? If so please let us know.

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Keywords: HEAT hydrochloride, supplier, selective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, BE2254, 2-{[b-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone, hydrochloride, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products

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