Cat. No. 0282
Chemical Name: (S)-(-)-3-Amino-1-hydroxypyrrolidin
Biological ActivityPossesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. R-enantiomer (Cat. No. 0281) also available.
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Grobaski et al (1997) Responses of rat substantia nigra dopamine-containing neurones to (-)-HA-966 in vitro. Br.J.Pharmacol. 120 575. PMID: 9051293.
Shepard and Lehmann (1992) (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor mediated mechanism. J.Pharmacol.Exp.Ther. 261 387. PMID: 1578355.
Singh et al (1990) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative. Proc.Natl.Acad.Sci.U.S.A. 87 347. PMID: 2153294.
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Keywords: (S)-(-)-HA-966, supplier, NMDA, antagonists, partial, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products
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