CGH 2466 dihydrochloride

Cat. No. 2344

CGH 2466 dihydrochloride C14H9N3SCl2.2HCl [1177618-54-0]

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Chemical Name: 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine dihydrochloride

Biological Activity

Adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.

Technical Data

M.Wt:
395.13
Formula:
C14H9N3SCl2.2HCl
Solubility:
Soluble to 10 mM in DMSO with gentle warming and to 5 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
1177618-54-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Trifilieff et al (2005) CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br.J.Pharmacol. 144 1002. PMID: 15685201.

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Keywords: CGH 2466 dihydrochloride, supplier, A1, A2B, A3, antagonists, inhibitors, inhibits, p38, MAPK, PDE4, Anti-inflammatory, agent, adenosines, receptor, Non-Selective, Receptors, Phosphodiesterases, CGH2466, dihydrochloride, Tocris Bioscience, Non-selective Adenosine Antagonist products

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