CGH 2466 dihydrochloride
Cat. No. 2344
Chemical Name: 4-(3,4-Dichlorophenyl)-5-(4-pyridin
Biological ActivityAdenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Trifilieff et al (2005) CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br.J.Pharmacol. 144 1002. PMID: 15685201.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses CGH 2466 dihydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: CGH 2466 dihydrochloride, supplier, A1, A2B, A3, antagonists, inhibitors, inhibits, p38, MAPK, PDE4, Anti-inflammatory, agent, adenosines, receptor, Non-Selective, Receptors, Phosphodiesterases, CGH2466, dihydrochloride, Tocris Bioscience, Non-selective Adenosine Antagonist products
Find multiple products by catalog number
New Products in this Area
High affinity adenosine A1 receptor antagonistISAM 140
High affinity A2B receptor antagonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.